Endocrine Abstracts

Objective: To report a patient with clinical hypothyroidism due to primary hypotriiodonaemia.Design: Case report.Main outcome: A 26-year-old woman presented with weight gain, cold intolerance, fatigue, mental lethargy, depression, long periods of amenorrhea and delayed ankle reflex relaxation. She was not on any medications. The (mean of two) thyroid stimulating hormone (TSH) concentrations was 2.5 (N: 3.8–5.5 mU/l), th...

Objective: To assess if adding slow-release liothyronine (SR-T3) to levothyroxine (l-T4) reduces persistent hypothyroid symptoms and signs on replacement with l-T4 alone.Design: Open label, two-period cross-over, cohort comparison. The main outcomes were changes in the serum T3 concentration and residual clinical hypothyroid indicants. Each study period was 10 weeks. The sample size required was d...

Objective: Report of hypothyroidism due to primary hypotriiodothyronaemia caused by a deficiency in peripheral generation.Design: Case report and computer modelling.Main outcome: A 28-year-old woman presented with hypothyroid symptoms and delayed ankle reflex relaxation times. She was not on any medications. The average thyroid stimulating hormone (TSH) concentrations was 2.5 (N: 3.8–5.5 mU/l), free thyroxine (T4) 12.3 ...